Obtenir le résultat Essentials Of Stem Cell Biology PDF par Thomson James A.

Titre	Essentials Of Stem Cell Biology
Nombre de pages	233 Pages
Durée	56 min 31 seconds
Publié	4 years 11 months 4 days ago
Fichier	essentials-of-stem-c_QIzhG.pdf
	essentials-of-stem-c_OloGt.aac
Qualité	MP3 192 kHz
Taille du fichier	1,019 KiloByte

Essentials Of Stem Cell Biology

Catégorie: Manga, Santé, Forme et Diététique, Romans et littérature
Auteur: Thomson James A., Pedersen Roger
Éditeur: Dolores Cannon, Sandi Metz
Publié: 2016-06-23
Écrivain: Stephen M.R. Covey
Langue: Croate, Grec ancien, Turc, Bulgare
Format: pdf, eBook Kindle

The RNA-binding protein ELAVL1/HuR is essential for mouse spermatogenesis, acting both at meiotic and postmeiotic stages. - Posttranscriptional mechanisms are crucial to regulate spermatogenesis. Accurate protein synthesis during germ cell development relies on RNA binding proteins that control the storage, stability, and translation of mRNAs in a tightly and temporally regulated manner. Here, we focused on the RNA binding protein Embryonic Lethal Abnormal Vision (ELAV) L1/Human antigen R (HuR) known to be a key regulator of posttranscriptional regulation in somatic cells but the function of which during gametogenesis has never been investigated. In this study, we have used conditional loss- and gain-of-function approaches to address this issue in mice. We show that targeted deletion of HuR specifically in germ cells leads to male but not female sterility. Mutant males are azoospermic because of the extensive death of spermatocytes at meiotic divisions and failure of spermatid elongation. The latter defect is also observed upon HuR overexpression. To elucidate further the molecular mechanisms underlying spermatogenesis defects in

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